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. 2020 May 18;15(5):e0233442. doi: 10.1371/journal.pone.0233442

Fig 6. Impact of drug substances on measured marker levels.

Fig 6

THBS1 and CTSD were measured in serum samples before and after spiking 7 pools of drug substances. Plots show the median, the 25 to 75% percentile (boxes) and minimum to maximum (whiskers) of relative serum levels of THBS1 (n = 4) (A) and CTSD (n = 3) (B) in samples with potentially interfering drugs, taking as 100% reference the levels in the respective non-spiked serum (carrier buffer only). Reported are p-values for TOST equivalence testing. (C) Spiked concentration and compositions of pools.