Figure 6.

Effects of HG and Si on expression of BMP2-related signaling pathway genes in hBMSCs. hBMSCs were treated with BMP2 signaling inhibitor noggin and Si ions (15.92 ppm) under NG or HG condition for 3 days. qPCR was performed for expression of BMP2 signaling pathway genes BMPR1A, BMPR1B, BMPR2, SMAD1, SMAD4 and SMAD5. The data are represented as mean ± S.D. *P < 0.05 and **P < 0.01 compared with NG control group. #P < 0.05 and ##P < 0.01 compared with HG group. NG, normal glucose; HG, high glucose; Si 15.92ppm represents the concentration of Si ions in medium