. 2019 Sep 30;90(Suppl 10):20–29. doi: 10.23750/abm.v90i10-S.8751

Table 2.

Genes associated with various forms of catecholaminergic polymorphic ventricular tachycardia

Gene	OMIM gene	Disease	OMIM disease	Inheritance	Function
RYR2	180902	CPVT1	604772	AD	Ca²⁺ channel triggers cardiac muscle contraction
CASQ2	114251	CPVT2	611938	AR	Regulates release of luminal Ca²⁺ via RYR2
TECRL	617242	CPVT3	614021	AR	Ca²⁺ transport into myocytes
CALM1	114180	CPVT4	614916	AD	Regulates release of Ca²⁺ via RYR2
TRDN	603283	CPVT5 with/without muscle weakness	615441	AR	Regulates release of luminal Ca²⁺ release via RYR1 and RYR2
KCNJ2	600681	CPVT	/	AD	Establishes action potential and excitability of neurons and muscles

AD=Autosomal dominant; AR=Autosomal recessive