Table 2.

Genes associated with oocyte maturation defect and preimplantation embryonic lethality

Gene	Inheritance	OMIM gene ID	OMIM phenotype	OMIM phenotype ID	Clinical Features
ZP3	AD	182889	OOMD3	617712	Oocyte degeneration, absence of zona pellucida
TUBB8	AD, AR	616768	OOMD2	616780	Oocyte arrest at metaphase I or II; abnormal spindle
ZP1	AR	195000	OOMD1	615774	Absence of zona pellucida
PATL2	AR	614661	OOMD4	617743	Oocyte maturation arrest in germinal vesicle stage, metaphase I or polar body 1 stage; abnormal polar body 1; early embryonic arrest
ZP2	AR	182888	OOMD6	618353	Abnormal of zona pellucida
TLE6	AR	612399	PREMBL1	616814	Failure of zygote formation
PADI6	AR	610363	PREMBL2	617234	Recurrent early embryonic arrest

OOMD=oocyte maturation defect; PREMBL=preimplantation embryonic lethality.