Table 1.
Polymorphisms identified from the literature as potential modifiers of neurotrophin-mediated neuroplastic activity
| Gene | Protein | Class | RefSeq | Nucleotide change | Amino acid change | MAF (GnomAD) | Ref |
| NGF | Beta-nerve growth factor | NTs | rs6330 | c.104C>T | Ala35Val | A=0.37015 (91127/246188) | 39 |
| BDNF | Brain-derived neurotrophic factor | NTs | rs6265 | c.196G>A | Val66Met | T=0.19437 (47821/246030) | 40 |
| NGFR | Beta-nerve growth factor receptor | NTs | rs2072446 | c.614C>T | Ser205Leu | T=0.05165 (12700/245884) | 39 |
| ADRB2 | Beta-2 adrenergic receptor | NTs | rs1042713 | c.46A>G | Gly16Arg | A=0.42081 (103492/245936) | 45 |
| ADRB2 | Beta-2 adrenergic receptor | NTs | rs1042714 | c.79C>G | Gln27Glu | G=0.31729 (78116/246198) | 45 |
| CNTF | Ciliary neurotrophic factor | NTs | rs1800169 | c.115-6G>A | A=0.14950 (35961/240538) | 46 | |
| MSTN | Growth/differentiation factor 8 | recovery | rs1805086 | c.458A>G | Lys153Arg | C=0.02732 (6704/245366) | 53 |
| ACTN3 | Alpha-actinin-3 | recovery | rs1815739 | c.1729C>T | Arg577* | T=0.46060 (113241/245854) | 55 |
| NTRK1 | High affinity nerve growth factor receptor | pain/NTs | rs6334 | c.1656G>A | Gln552His | A=0.22025 (54107/245664) | 57 |
| SCN9A | Sodium channel protein type 9 subunit alpha | pain | rs6746030 | c.3448C>T | Arg1150Trp | A=0.12050 (18374/152480) | 60 |
| COMT | Catechol O-methyltransferase | pain | rs4680 | c.322G>A | Val158Met | A=0.46252 (112239/242666) | 66 |
Legend: NTs, neurotrophins; RefSeq, polymorhism accession number as recorded in the database of single nucleotide polymorphisms; MAF, minor alle frequency; Ref, reference.