Table 4.

Anthropometric data (Mean± SD) in 2 groups of children with Down Syndrome (DS) ( >1 yr) with high TSH before and after treatment with L-thyroxine compared to DS subjects with normal thyroid function

Groups		Age-1 (yr)	Ht-SDS (1)	BMI-SDS (1)	Age-2 (yr)	Ht-SDS (2)	BMI-SDS (2)	Δ Ht-SDS	Δ BMI-SDS
TSH >12 mIU/L or FT4 <9 pmol/L	Mean	3.86	-2.15	-0.77	7.73	-2.39	0.66*	-0.24	1.43
Treated	SD	5.63	1.46	2.63	5.52	1.01	1.69	1.32	2.49
TSH >5 and <12 mIU/L	Mean	2.88	-1.57	0.38	8.88	-2.18	1.37*	-0.62	1.23
Treated	SD	2.70	1.04	1.82	5.04	1.27	1.98	1.09	3.25
Normal thyroid function	Mean	1.64	-1.90	-0.13	4.65	-2.08	0.59*	-0.17	0.69
	SD	2.03	1.36	1.68	2.81	0.93	1.48	0.97	1.41
P value		0.08	0.1182	0.089	<0.00	0.47	0.29	0.21	0.28

Abbreviations: 1 = before treatment, 2 = after treatment with L-thyroxine