Table 2.

Review of the metabolic changes reported in patients with precocious puberty treated with GnRHa

Authors and references	Results
Taşcilar ME et al. Turk J Pediatr. 2011;53:27-33.	An exaggerated elevation in trunk fat mass and insulin resistance (IR) in GnRHa-treated ICPP children was observed.
Sorensen K et al. Eur J Endocrinol. 2012;166:903-10.	Fasting insulin, first phase insulin release and mean plasma insulin during oral glucose tolerance test in CPP patients increased after a 52-week period of GnRHa treatment, whereas whole body insulin sensitivity index decreased, indicating an insulin resistance.
Park J et al. Ann Pediatr Endocrinol Metab.2017;22:27-35.	No changes were observed in QUICKI and HOMA-IR within a year of treatment in the normal-weight girls with CPP.
Arcari AJ et al. J Pediatr Endocrinol Metab. 2019;32:181-6.	GnRHa did not affect BMI, insulin index and lipid profile. However, an increase of BMI in girls with normal weight was observed.