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. 2019 Sep 6;90(3):345–359. doi: 10.23750/abm.v90i3.8736

Table 4.

Review of psychosocial changes in girls with precocious puberty before and during treatment with GnRHa

Authors and references Results
Xhrouet-Heinrichs D et al. Acta Paediatr. 1997; 86:808-15. Some behavioral and affective characteristics were observed in girls with PP. During treatment with long acting triptorelin, problematic behavior and functioning decrease slightly, particularly in the few girls showing breast regression.
Officioso A et al. J Pediatr Endocrinol Metab. 2000 Jul;13 Suppl 1:835-9. Ten adolescent girls aged 14 years treated for ICPP were evaluated. All the adolescents had a negative body image compared with age-matched controls and expressed a strong inhibition of their femininity. Their poor body image was reflected by their low self-esteem. A psychological support was recommended.
Mul D et al. Acta Paediatr. 2001;90:965-71. The psychological evaluation did not reveal any consistent abnormalities in adopted children with early puberty. Treatment with GnRHa with or without rhGH did not increase emotional and behavioural problems in adopted children, nor was their self-perception decreased.
Zheng F et al. Zhejiang Da Xue Xue Bao Yi Xue Ban. 2008; 37: 289-94. The authors compared the psychological behavior of girls with ICPP before and after treatment by GnRHa. They found that the self-esteem scale, and body-esteem scale score in ICPP were significantly lower compared to controls (P <0.05).
Kim YJ et al. Ann Pediatr Endocrinol Metab 2013;18:173-8. The psychological assessment did not exhibit a significant difference except with scores for sociability and behavior problems.
Choi MS et al. Ann Pediatr Endocrinol Metab. 2016; 21:155-60. Patients with PP had distorted perception about their body image and breast development that seems to contribute to depression score.
Schoelwer MJ et al. Horm Res Paediatr. 2017; 88:347-53. Girls with CPP completed psychological assessments at baseline and after 1 year along with their mothers. All girls were treated with GnRH analogs. Psychological measures were normal in all girls.