Table 6.

Summary of patients with central precocious puberty developing arterial hypertension during GnRHa treatment

Authors and references	Results
Calcaterra V et al. Indian J Pediatr. 2013;80:884-885.	A 7-year-old girl with triptorelin-treated CPP, who developed reversible HTN with secondary concentric left ventricular hypertrophy, requiring transient antihypertensive therapy.
Siomou E et al. Pediatr Nephrol. 2014;29:1633-1636	A 10-year-old girl with a Williams-Beuren syndrome and CPP who developed HTN with triptorelin treatment. In that case, blood pressure totally normalized, without any anti-hypertensive medication once GnRHa was discontinued.
Palma L et al. J Pediatr Endocrinol Metab. 2018 Aug 8. pii: /j/jpem. ahead-of-print/jpem-2018-0210/jpem-2018-0210.xml. doi: 10.1515/jpem-2018-0210	A girl with CPP who developed HTN from treatment with GnRH-a (triptorelin). HTN subsided once triptorelin was interrupted. Consequently, the Authors hypothesized that the hypertension was related to triptorelin treatment.
Sifaki L et al. Front Pediatr. 2019 Mar 19;7:74. doi: 10.3389/ fped. 2019.00074.	A 10-year-old girl with CPP during treatment with triptorelin, developed an asymptomatic stage II HTN. Initial workup showed no renal, thyroid, or electrolytes abnormalities. A complete normalization of her blood pressure was obtained without any medication.