. Author manuscript; available in PMC: 2021 Jan 1.

Published in final edited form as: Mov Disord. 2019 Oct 29;35(1):5–19. doi: 10.1002/mds.27867

Table 2.

Phenotypic Differences in LBD by Neuropathologic Subtype

	PD/PDD		DLB
	SYN-AD	SYN+AD	SYN-AD	SYN+AD

Age of Onset, (range of mean age)	Younger (57–66)	Older (68–74) ^{21, 25, 94, 65 ,69, 97}	Similar (68–78)	Similar (70–85) ^{21, 29, 94}
Motor Dementia Interval, (range of mean years)	Longer (8–15)^**	Shorter (2–10) ^{21, 32, 69, 97***}	NA
Survival (range of mean years)	Longer^* (10–19)	Shorter (4.5–13) ^{21, 25, 65, 69, 97, 98}	Longer (6–10)	Shorter (3–7) ^{21, 29, 94}
Motor Phenotype	More prominent rest tremor	Greater relative postural instability gait disorder ^{25, 32, 106}	No clear data examining influence of AD co-pathology but overall DLB has less common rest tremor and more prominent postural instability ^{114, 132}
Hallucinations/Fluctuations	No clear data comparing influence of AD co-pathology but hallucinations/fluctuations are common in PDD ¹⁴		More frequent	Less frequent ^{13, 31, 103}
Cognitive Dysfunction	Executive, attention, visuospatial deficits	Additional episodic memory, naming deficits^{3, 105}	Executive, attention, visuospatial deficits	Additional episodic memory, naming deficits^{94, 104, 105}
Genetic Associations	GBA mutation carriers ++ APOE ε4 allele carriers +	GBA mutation carriers + ²²¹ APOE ε4 allele carriers ++^{16, 226, 227, 228}	GBA mutation carriers ++, APOE ε4 allele carriers +	GBA mutation carriers +, ^{214, 221} APOE ε4 allele carriers ++ ^{212, 226, 227, 228}

not published data

^**

some studies also describe small groups of patients with SYN-AD pathology and a more fulminant course 69, 95, 103, 107

^***

Several studies do not directly report motor dementia interval but rather cite that PDD patients are more likely to harbor SYN+AD pathology rather than SYN-AD (2, 25, 32, 66, 69).

SYN-AD: Synuclein neuropathology with no or low level AD co-pathology, SYN+AD: Synuclein pathology with moderate or high level AD co-pathology. NA: not applicable, DLB clinical syndrome defined by Motor dementia interval ≤ 1year.