Table 2. Genes from differential analysis of B16F10L tumors from A-I Tg+/– versus A-I KO mapped to key cancer related biological processes.
| Biological Processes | Up-regulated genes in A-ITg | Down-regulated genes in A-ITg |
|---|---|---|
| Proliferation | Axin2, Cd44, Cd80, Cdk2, Cxcr4, Dnajb1, Dusp1, Enpp2, Fbln1, Hspa1a, Irx3, Irx5, Klf9, Ltbp3, Mapt, Mitf, Mknk2, Nfat5, Osmr, Peli1, Per1, Phlda1, Pik3r3, Ptprs, Sort1, Srebf1, Srgn, St6gal1, Tnfaip3, Tob2, Tyr | Adamts1, Apex1, Cdc20, Cirbp, Dhcr24, Dicer1, Eif5a, Exosc4, Fadd, Gorasp2, Mbp, Mcm3, Mvd, Phgdh, Slc19a1, Tmpo, Vti1a |
| Apoptosis | Axin2, Cd44, Cdk2, Cxcr4, Dnajb1, Dusp1, Enpp2, Fbln1, Hspa1a, Ltbp3, Luc7l3, Map3k12, Mapt, Mitf, Nfat5, Peli1, Per1, Phlda1, Pik3r3, Ptprs, Snca, Sort1, Srgn, St6gal1, Tnfaip3, Tyr | Alg5, Apex1, Cdc20, Dhcr24, Dhx9, Dicer1, Eif5a, Fadd, H47, Lims2, Mbp, Slc19a1, Tcte3, Ubqln1 |
| Inflammation | C2, Cd44, Cdk2, Cxcr4, Dusp1, Osmr, Per1, Srebf1, Srgn, St6gal1, Tnfaip3, Tyr | Dicer1, Fadd, H47, Mbp, Stx18 |
| Immune response | C2, Cd44, Cd80, Cdk2, Cxcr4, Dusp1, Enpp2, Hspa1a, Klf9, Mitf, Osmr, Peli1, Per1, Snca, Srebf1, St6gal1, Tnfaip3, Tob2, Tyr | Dicer1, Fadd, H47, Mbp, Slc19a1 |
| Angiogenesis | Robo4, Cd44, Cxcr4 | Dicer1, Wars |
| Metastasis | C2, Cd44, Cxcr4, Dusp1, Enpp2, Fbln1, Map3k12, Mapt, Nfat5, Pik3r3, Robo4, Sema6d, Sort1, Srebf1, St6gal1, Tnfaip3 | Apex1 |
| Chemotaxis | Cd44, Cytip, Enpp2, Ptprs, Dusp1 | Pcdh17 |
| Leukocyte infiltration | Cd44, Cxcr4, Cytip, Mitf, Pik3r3, Snca | Dicer1 |
| Cancer | Cd44, Cdk2, Cxcr4, Enpp2, Klf9, Mitf, Osmr, Pik3r3, Srgn, Tnfaip3, Tyr | Adamts1, Cdc20, Cirbp, Dicer1, Fadd, Insig1, Mcm3, Mvd, Nme4, Slc19a1, Sqle, Srm |
| Stress response | Axin2, C2, Cd44, Dnajb1, Hspa1a, Insig2, Luc7l3, Peli1, Snca, Srebf1, Tnfaip3 | Apex1, Cirbp, Dhx9, Dicer1, Fadd, H47, Insig1, Mpv17, Rad51ap1, Sfrs5, Ubqln1, Wfdc12 |
| DNA damage/repair | Cdk2, Dnajb1, Dusp1, Hspa1a, Map3k12, Srgn | Apex1, Cdc20, Dicer1, Mcm3, Nme4, Nup107, Slc19a1, Tmpo |
| Cell differentiation | Axin2, Cd44, Cxcr4, Erdr1, Irx3, Irx5, Ltbp3, Mapt, Mitf, Robo4, Sema6d, Sort1, Tob2 | AI428936, Camk1, Cdc20, Dicer1, Eif5a, Insig1, Mbp, Nle1, Phgdh, Stk25 |
| Transport | Acsl3, Axin2, Cd44, Cdk2, Cxcr4, Elovl5, Insig2, Mapt, Ptprs, Snca, Sort1, Srebf1, Srgn | Apex1, Camk1, Dhcr24, Dync1i1, Eif5a, Fadd, H47, Il1rl1l, Insig1, Mbp, Mybbp1a, Nup107, Phgdh, Preb, Rhobtb3, Slc19a1, Snf8, Srpr, Stard4, Stard5, Stx18, Tmed4, Vti1a, Yif1a, Zfpl1 |
| Other Processes | 2700097009Rik, Acss2, Ahnak2, Bace2, Clmn, Crem, Dkk3, Efcab6, Eif4a2, Fbxo30, Gcnt2, Gpr158, Gsta4, Hs3st1, Lekr1, Loc100043671, Loc100046802, Loc677317, Nckap5l, Plekha3, Rdm1, Tex2, Ube2o, Unc119b, Zfp597, Zmynd8 | Get4, 1810065E05Rik, 2410002F23Rik, Fam176b, 3010003L21Rik, Trmt61a, Bud31, C85627, Cyp51a1, Dus1l, Elovl1, Fbp2, Fbxo36, Gale, Gmpr, Grwd1, Hm13, Hsd17b7, Oc100040592, Loc100043257, Mest, Mpdu1, Mrps18b, Msto1, Nif3l1, Nol12, Nop56, Mak16, Rnf144a, Rnf25, Rwdd3, Sc4mol, Smyd5, Snrpa, Sssca1, Sumo3, Tmem17, Tmem214, Ttc39a, Znf32 |
List of genes mapped to key cancer-related processes in Figure 4. List of significant genes mapped to processes relevant to cancer.