. 2020 May 12;11(19):1777–1796. doi: 10.18632/oncotarget.27590

Table 4. Mouse genes differentially regulated in B16F10L tumors from A-I KO and A-I Tg^+/– mice and concordant with human genes associated with poor outcome in melanoma were mapped to top functions in IPA.

Expression in A-I KO relative to A-I Tg mice	Gene Symbol	Top Functions
↑	Atad2, Birc5, Cdca8, Cdk1, Cenpa, Dtymk, Htra2, Kif2c, Mcmr, Mcm6, Melk, Nasp, Ndc80, Psmc3ip, Ran, Ranbp1, Rrm2, Srp19, Timeless, Tyms	DNA Replication, Recombination and Repair, Cellular Assembly and Organization, Nucleic Acid Metabolism
↓	F10, Hla-dqb1
↑	Anln, Atad2, Cdc45, Cdc14b, Gpn3, Kpna2, Mrps16, Mrps17, Nans, Ncapg2, Ncaph, Rfc4, Shcbp1, Tyms	Cell Cycle, DNA Replication, Recombination and Repair, Cellular Assembly and Organization
↑	Kdelr2, Loc100505793/Fusip1, Ncp1, Ncoa6, Ola1, Prim2, Rbmx, Rfc5, Srp19, Surf4, Tars, Trub2	Cell Cycle, Cancer, Infection Mechanism
↑	Cdca5, Gemin6, Hspd1, Nme1, Rfc4, Rfc5, Snrpg, Tcof1, Tk1, Top2a	Cell Cycle, DNA Replication, Recombination and Repair, Developmental Disorder

Genes whose expression in A-I KO relative to A-I Tg^+/– were determined to be concordant with a subset of genes previously identified in a human study [8] to track with poor outcome in melanoma (Table 3), were mapped to top functions in Ingenuity Pathway Analysis (IPA) and are shown in Table 4. Arrows indicate the direction of expression of these genes in day 7 B16F10L tumors from A-I KO relative to A-I Tg^+/– animals.

Table 4. Mouse genes differentially regulated in B16F10L tumors from A-I KO and A-I Tg+/– mice and concordant with human genes associated with poor outcome in melanoma were mapped to top functions in IPA.

Table 4. Mouse genes differentially regulated in B16F10L tumors from A-I KO and A-I Tg^+/– mice and concordant with human genes associated with poor outcome in melanoma were mapped to top functions in IPA.