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. 2020 Apr 27;8:2050313X20910599. doi: 10.1177/2050313X20910599

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© The Author(s) 2020

This article is distributed under the terms of the Creative Commons Attribution-NonCommercial 4.0 License (https://creativecommons.org/licenses/by-nc/4.0/) which permits non-commercial use, reproduction and distribution of the work without further permission provided the original work is attributed as specified on the SAGE and Open Access pages (https://us.sagepub.com/en-us/nam/open-access-at-sage).

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Figure 1. — Chronic painful vasculitic wound due to polyarteritis nodosa. (a) Painful wound on the left leg measured 6.7 × 4.5 × 0.1 cm³ at initial presentation and was treated with negative pressure wound therapy (NPWT) and dressing changes. (b) At week 2, there was lack of epithelialization and pain was still severe (8–9/10), so umbilical cord (UC) allograft was applied. Pain resolved overnight (0/10), and the patient discontinued opioid use. NPWT was discontinued at week 3. (c) At week 4, a second UC graft was placed. (d) By week 11, progressive wound healing was evident along with remnant UC graft. (e) At week 12, an injection of 25 mg of AM/UC particulate was administered. (f) Complete wound closure with return of pigmentation was evident by week 19, following a second AM/UC particulate injection 2 weeks prior.