Table 5.
Studies reporting acute psychiatric and neuropsychiatric outcomes of SARS-CoV-2 infections
| Preprint | Setting | Virus subtype | Study design | Special population | Sample size | Mean (SD)*age, years | Male cases (%) | Females cases (%) | Outcomes | |
|---|---|---|---|---|---|---|---|---|---|---|
| Moriguchi et al (2020)64 | No | Japan | SARS-CoV-2 | Case report | .. | 1 case | 24 (NR) | 1 (100%) | 0 | Symptom: impaired consciousness; diagnosis: meningitis-encephalitis |
| Helms et al (2020)61 | No | France | SARS-CoV-2 | Case series | ICU admissions | 58 cases | NR | NR | NR | Symptoms: agitation, confusion, inattention, disorientation, and poorly organised movements in response to command; diagnoses: dysexcutive syndrome and encephalopathy; investigations: MRI brain, EEG, and CSF analysis |
| Chen et al (2020)63 | No | Wuhan, China | SARS-CoV-2 | Cohort | .. | 99 cases | 55·5 (13·1) | 67 (68%) | 32 (32%) | Symptom: confusion |
| Chen et al (2020)62 | No | Wuhan, China | SARS-CoV-2 | Cohort | .. | 21 cases | Median 56·0 (IQR 50·0–65·0) | 17 (81%) | 4 (19%) | Symptom: coma; diagnosis: hypoxic encephalopathy |
| Zhang et al (2020)98 | Yes | Wuhan, China | SARS-CoV-2 | Cohort | Deaths | 82 cases | Median 72·5 (IQR 65·0–80·0) | 54 (66%) | 28 (34%) | Symptom: consciousness problem |
| Qi et al (2020)100 | Yes | Chongqing, China | SARS-CoV-2 | Cohort | .. | 267 cases | Median 48·0 (IQR 35·0–65·0) | 149 (56%) | 118 (44%) | Symptom: confusion |
| Huang et al (2020)99 | Yes | Wuhan, China | SARS-CoV-2 | Cohort | Deaths | 36 cases | 69·2 (9·6) | 25 (69%) | 11 (31%) | Symptom: disturbance of consciousness |
| Mao et al (2020)23 | No | Wuhan, China | SARS-CoV-2 | Cohort | .. | 214 cases | 52·7 (15·5) | 87 (40%) | 127 (60%) | Symptom: impaired consciousness |
| Leung et al (2020)101 | Yes | Hong Kong | SARS-CoV-2 | Cohort | .. | 50 cases | 55·2 (19·5) | 23 (46%) | 27 (54%) | Symptom: confusion |
| Fu et al (2020)102 | Yes | Wuhan, China | SARS-CoV-2 | Cohort | .. | 50 cases | Median 64·0 (IQR 37·0–87·0) | 27 (54%) | 23 (46%) | Symptom: insomnia |
| Yang et al (2020)97 | Yes | Zhejiang, China | SARS-CoV-2 | Cohort | .. | 26 cases, 87 pneumonia controls, 30 healthy controls | Mean 56·0 (range 27·0–86·0) | 9 (35%) | 17 (65%) | Scales: HAMD and HAMA |
| Kong et al (2020)96 | Yes | Wuhan, China | SARS-CoV-2 | Cross-sectional | .. | 144 cases | 50·0 (13·7) | 70 (49%) | 74 (51%) | Scales: HADS and PSSS |
CSF=cerebrospinal fluid. EEG=electroencephalogram. HADS=Hospital Anxiety and Depression Scale. HAMA=Hamilton Anxiety Scale. HAMD=Hamilton Depression Scale. ICU=intensive care unit. NR=not reported. PSSS=Perceived Social Support Scale. SARS-CoV-2=severe acute respiratory syndrome coronavirus 2.
*
Data are mean (SD) unless otherwise stated.