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. Author manuscript; available in PMC: 2020 May 18.
Published in final edited form as: Bioconjug Chem. 2018 Oct 24;29(12):3937–3966. doi: 10.1021/acs.bioconjchem.8b00548

Figure 11. Immunoglobulin G (IgG) access to the perivascular space (PVS) surrounding cerebral blood vessels following intrathecal and intranasal delivery.

Figure 11.

(A, B) Examples of blood vessels at the rat the cortical surface and in the striatum respectively showing intrathecally administered rat IgG accessing the PVS. (C, D) Examples of blood vessels in the rat olfactory bulb and at the cortical surface respectively showing intranasally administered rat IgG accessing the PVS. Abbreviations: IT – intrathecal; IN – intranasal; RECA-1 – rat endothelial cell antigen-1 (endothelial cell marker); GFAP – glial fibrillary acidic protein (astrocyte marker); DAPI – 4’, 6-diamidino-2-phenylindole (cell nucleus marker).