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. Author manuscript; available in PMC: 2020 May 18.
Published in final edited form as: Biochem Pharmacol. 2019 Mar 15;164:34–44. doi: 10.1016/j.bcp.2019.03.024

Fig. 1. Lira promotes osteoinduction and bone regeneration at the femur osteotomy site of normal and osteopenic rats.

Fig. 1

(A) 24 h after making a 0.8 mm drill-hole at femur of adult female rats Lira treatment at indicated doses were given for 12 d. Representative confocal images (10×) showing calcein deposition in callus in various groups (upper panel). Quantification of mean calcein intensity per pixel in the callus is shown in the bottom panel. (B) Post-OVX induction of osteopenia in adult rats demonstrated by bone mineral density (BMD) and bone volume (BV/TV %) at proximal femur. (C) OVX osteopenic rats with drill-hole injury as described in panel A were treated with vehicle or Lira for 12 days. Shown are representative calcein labeling (upper left) and μCT images (bottom left) and quantification of mean calcein intensity and BV/TV (right panels). Data are expressed as mean ± SEM (n = 10/group); **P < 0.01 and ***P < 0.001 versus vehicle control.