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. Author manuscript; available in PMC: 2020 Aug 1.
Published in final edited form as: Nature. 2019 Dec 25;578(7795):444–448. doi: 10.1038/s41586-019-1911-y

Extended Data Figure 2. Effect of single oral dose of metformin in chow fed mice.

Extended Data Figure 2

Serum GDF15 levels in male mice measured 2, 4, or 8 hours after a single gavage dose of metformin (300mg/kg). a, mice ad libitum overnight fed prior to gavage. b, mice fasted for 12 hour prior to gavage. Data are mean ± SEM (a; n=6/group, b; n= 4/group); P by 2-way ANOVA with Tukeys correction for multiple comparisons.