Table 4.
Univariate and Multivariate Analysis of Factors Associated with SVR at 12 Weeks in Patients with G3-HCV Cirrhosis with or without RBV
| Variable | Univariable model | Multivariable model | |||
|---|---|---|---|---|---|
| SVR12 (%) | OR (95% CI) | p-value | OR (95% CI) | p-value | |
| Female vs male | 94.6 vs 94.4 | 1.0 (0.2–4.8) | 0.6 | - | - |
| Diabetes (no vs yes) | 96.4 vs 85.3 | 4.7 (1.4–16.0) | 0.01 | 2.0 (0.4–9.8) | 0.3 |
| Arterial hypertension (no vs yes) | 96.4 vs 87.5 | 4.6 (1.3–15.4) | 0.02 | 3.6 (0.73–18) | 0.1 |
| Cryoglobulinemia (no vs yes) | 94.8 vs 94.4 | 1.0 (0.13–9.3) | 0.6 | - | - |
| BMI (≤25 kg/m2 vs >25 kg/m2) | 94.0 vs 95.6 | 0.72 (0.2–2.3) | 0.4 | - | - |
| PLT (≤100×103/μL vs >100×103/μL) | 95.3 vs 94.5 | 1.1 (0.3–4.1) | 0.5 | - | - |
| HCV RNA (≤800,000 IU/mL vs >800,000 IU/mL) | 93.5 vs 95.7 | 0.65 (0.19–2.2) | 0.3 | - | - |
| CPT (A vs B/C) | 96.1 vs 82.1 | 5.3 (1.6–17.7) | 0.01 | 5.3 (1.3–21.1) | 0.01 |
| Esophageal varices (no vs yes) | 94.3 vs 98.0 | 0.33 (0.03–2.9) | 0.2 | - | - |
| Naïve vs experienced | 96.0 vs 92.7 | 1.88 (0.59–5.9) | 0.2 | - | - |
| No RBV vs RBV | 87.1 vs 97.5 | 0.17 (0.05–0.57) | 0.003 | 0.27 (0.07–1.0) | 0.05 |
SVR, sustained viral response; G3-HCV, genotype 3 hepatitis C virus; RBV, ribavirin; OR, odds ratio; CI, confidence interval; BMI, body mass index; PLT, platelets; CPT, Child-Pugh-Turcotte.