Table 3.
Results of mediation analysis on the effect of having an ND-CNV on (A) ADHD symptom counts, (B) ASD trait symptom count, (C) anxiety symptoms and (D) ODD symptoms with coordination ability as a mediator
| Estimates | Lower 95% CI | Upper 95% CI | p | |
|---|---|---|---|---|
| (A) ADHD symptom counts | ||||
| Average causal mediation effects | 2.54 | 1.04 | 4.24 | 0.001 |
| Average direct effects | 2.39 | 0.13 | 4.44 | 0.042 |
| Total effects | 4.93 | 3.67 | 6.10 | <0.001 |
| Prop. mediated | 0.51 | 0.20 | 0.97 | 0.001 |
| (B) ASD trait symptom counts | ||||
| Average causal mediation effects | 8.13 | 6.14 | 10.44 | <0.001 |
| Average direct effects | 4.14 | 1.16 | 6.95 | 0.005 |
| Total effects | 12.27 | 10.44 | 14.06 | <0.001 |
| Prop. mediated | 0.66 | 0.48 | 0.90 | <0.001 |
| (C) Anxiety symptom counts | ||||
| Average causal mediation effects | 1.84 | 0.35 | 3.45 | 0.012 |
| Average direct effects | 0.81 | −1.24 | 2.79 | 0.428 |
| Total effects | 2.65 | 1.42 | 3.89 | <0.001 |
| Prop. mediated | 0.69 | 0.12 | 1.71 | 0.012 |
| (D) ODD symptom counts | ||||
| Average causal mediation effects | 0.27 | −0.26 | 0.80 | 0.304 |
| Average direct effects | 0.91 | 0.16 | 1.66 | 0.017 |
| Total effects | 1.18 | 0.70 | 1.64 | <0.001 |
| Prop. mediated | 0.23 | −0.22 | 0.82 | 0.304 |
Average causal mediation effects corresponds to the indirect effect through coordination ability, while average direct effects correspond to the direct effect of having an ND-CNV on the psychopathology variable of interest.