Table 4.

Results of mediation analysis on the effect of having an ND-CNV on (A) full scale IQ, (B) performance IQ and (C) verbal IQ with coordination ability as a mediator

	Estimates	Lower 95% CI	Upper 95% CI	p
(A) FSIQ
Average causal mediation effects	−7.12	−12.17	−2.58	0.002
Average direct effects	−10.86	−17.06	−4.81	<0.001
Total effects	−17.98	−22.02	−13.98	<0.001
Prop. mediated	0.40	0.14	0.70	0.002
(B) PIQ
Average causal mediation effects	−6.68	−11.79	−2.08	0.005
Average direct effects	−9.89	−16.03	−3.39	0.005
Total effects	−16.57	−20.76	−12.39	<0.001
Prop. mediated	0.40	0.12	0.76	0.005
(C) VIQ
Average causal mediation effects	−6.21	−11.14	−1.81	0.006
Average direct effects	−10.28	−16.66	−3.75	0.004
Total effects	−16.49	−20.71	−12.18	<0.001
Prop. mediated	0.38	0.11	0.74	0.006

Average causal mediation effects correspond to the indirect effect through coordination ability, while average direct effects correspond to the direct effect of having an ND-CNV on the psychopathology variable of interest.