Table 2.

Association between polyp subtypes and incidence and mortality of colorectal cancer

	Reference individuals	Hyperplastic polyps	SSA/Ps	Tubular adenomas	Tubulovillous adenomas	Villous adenomas	Synchronous serrated polyps and conventional adenomas
Colorectal cancer incidence
No. of events	14,350	878	77	1,361	1,406	176	380
No. of person-years	6,780,775	492,177	28,669	475,543	250,726	18,884	97,315
Incidence rate (per 10,000 person-years)	21.2	17.8	26.9	28.6	56.1	93.2	39.0
HR (95% CI)*	1 (ref)	0.97 (0.90-1.05)	1.54 (1.17-2.02)	1.23 (1.15-1.31)	2.26 (2.11-2.42)	3.38 (2.73-4.18)	1.58 (1.40-1.79)
P*		0.51	0.002	<0.0001	<0.0001	<0.0001	<0.0001
HR (95% CI)†	1 (ref)	1.11 (1.02-1.22)	1.77 (1.34-2.34)	1.41 (1.30-1.52)	2.56 (2.36-2.78)	3.82 (3.07-4.76)	1.84 (1.61-2.10)
P†		0.02	<0.0001	<0.0001	<0.0001	<0.0001	<0.0001
Colorectal cancer mortality
No. of events	5,242	253	26	366	461	67	96
No. of person-years	6,836,937	496,164	28,968	482,787	258,013	19,971	99,088
Mortality rate (per 10,000 person-years)	7.7	5.1	9.0	7.6	17.9	33.5	9.7
HR (95% CI)*	1 (ref)	0.83 (0.72-0.95)	1.61 (1.01-2.56)	0.89 (0.79-1.01)	1.83 (1.63-2.06)	3.30 (2.33-4.66)	1.11 (0.88-1.41)
P*		0.008	0.05	0.06	<0.0001	<0.0001	0.37
HR (95% CI)†	1 (ref)	0.90 (0.76-1.06)	1.74 (1.08-2.79)	0.97 (0.84-1.12)	1.95 (1.69-2.24)	3.45 (2.40-4.95)	1.20 (0.93-1.55)
P†		0.20	0.02	0.63	<0.0001	<0.0001	0.16

Abbreviations: CI, confidence interval; HR, Hazard ratio; SSA/Ps, sessile serrated adenoma/polyps.

^*The matching factors including birth year, age, sex, and county of residence were automatically adjusted for by the stratified Cox regression.

^†Further adjusted for family history of CRC (yes, no), income levels (quintiles), education (9 years or less, 10-12 years, >12 years, missing), number of prior clinic visits at baseline (quintiles), and number of prior colonoscopies or sigmoidoscopies at baseline (0, 1, 2 and >2).