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. Author manuscript; available in PMC: 2021 Apr 1.
Published in final edited form as: Curr Hematol Malig Rep. 2020 Apr;15(2):103–112. doi: 10.1007/s11899-020-00565-6

Table 2.

Current immunosuppressive therapies for LGL leukemia.

Type of treatment Typical treatment dose & duration Additional information
Immunosuppressive therapy
Methotrexate 10 mg/m2 per week; taken indefinitely First-line; especially for neutropenic patients
Cyclophosphamide 100 mg per day; taken up to 12 months Typically used for patients with anemia, especially PRCA (typically non-responders to methotrexate).
Cyclosporine A 3 mg/kg per day; taken indefinitely Prescribed if patients fail the previous two treatments.
Prednisone 1 mg/kg orally daily 30 days then tapered off 24 days Typically given in combination with methotrexate [20]