Table 2.
The association of body mass index and non-cardia gastric cancer risk, the H. pylori Biomarker Cohort Consortium (HpBCC)
| BMI (kg/m2) | Cases N (%) |
Controls N (%) |
OR (95% CI)1 | OR (95% CI)2 | OR (95% CI)3 | OR (95% CI)4 | OR (95% CI)5 |
|---|---|---|---|---|---|---|---|
| < 18.5 | 59 (4.1) | 51 (2.8) | 1.63 (1.09, 2.44) | 1.56 (1.04, 2.34) | 1.70 (1.12, 2.58) | 1.56 (1.03, 2.36) | 1.59 (1.05, 2.41) |
| 18.5–20.0 | 145 (10.1) | 153 (8.5) | 1.34 (1.03, 1.76) | 1.31 (1.00, 1.71) | 1.30 (0.98, 1.71) | 1.33 (1.01, 1.76) | 1.33 (1.01, 1.76) |
| 20.1–22.5 | 477 (33.4) | 496 (27.7) | 1.37 (1.14, 1.66) | 1.37 (1.13, 1.65) | 1.34 (1.10, 1.62) | 1.39 (1.15, 1.69) | 1.38 (1.14, 1.68) |
| 22.6–25.0 | 368 (25.7) | 557 (31.1) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) | 1.00 (reference) |
| 25.1–27.5 | 215 (15.1) | 340 (19.0) | 1.02 (0.82, 1.27) | 1.00 (0.81, 1.25) | 0.99 (0.79, 1.24) | 1.01 (0.80, 1.26) | 1.00 (0.80, 1.25) |
| >27.5 | 166 (11.6) | 195 (10.9) | 1.53 (1.19, 1.97) | 1.48 (1.15, 1.91) | 1.52 (1.17, 1.97) | 1.48 (1.14, 1.91) | 1.46 (1.13, 1.89) |
Conditional logistic regression stratified by cohort
Conditional logistic regression stratified by cohort, and additionally adjusted for age, sex, smoking status (within those without missing values of smoking).
Conditional logistic regression stratified by cohort, and additionally adjusted for age, sex, smoking status, and dual Omp/HP0305 sero-positivity
Conditional logistic regression stratified by cohort, and additionally adjusted for age, sex, smoking status, and H. pylori infection (+ vs. −)
Conditional logistic regression stratified by cohort, and additionally adjusted for age, sex, smoking status, and H. pylori and CagA status (HP-, HP+CagA-, and HP+CagA+)