. Author manuscript; available in PMC: 2021 Aug 1.

Published in final edited form as: Int J Cancer. 2019 Dec 12;147(3):777–784. doi: 10.1002/ijc.32790

Table 3.

The association of body mass index and non-cardia gastric cancer risk by H. pylori infection, the H. pylori Biomarker Cohort Consortium (HpBCC)

A. Stratification analysis by H. pylori antibody status³
BMI (kg/m²)	H. pylori −		H. pylori +		H. pylori +CagA+
BMI (kg/m²)	Ca/Co¹	OR (95% CI)²	Ca/Co¹	OR (95% CI)²	Ca/Co¹	OR (95% CI)²
< 18.5	4/11	0.88 (0.24, 3.22)	55/40	1.63 (1.05, 2.53)	49/35	1.60 (1.00, 2.55)
18.5–20.0	18/30	1.69 (0.77, 3.71)	127/123	1.28 (0.95, 1,72)	123/109	1.37 (1.01, 1.86)
20.1–22.5	37/115	0.97 (0.52, 1.78)	440/381	1.45 (1.19, 1,78)	420/353	1.47 (1.19, 1.81)
22.6–25.0	26/97	1.00 (reference)	342/460	1.00 (reference)	322/424	1.00 (reference)
25.1–27.5	15/55	1.15 (0.55, 2.44)	200/285	1.00 (0.79, 1.27)	188/267	0.98 (0.77, 1.25)
>27.5	7/32	0.84 (0.32, 2.20)	159/163	1.55 (1.18, 2.03)	155/151	1.59 (1.21, 2.11)
B. Stratification analysis by H. pylori Omp and HP0305 antibody biomarker⁴
BMI (kg/m²)	Omp− and HP0305-		Omp+ or HP0305+		Omp+ and HP0305+
BMI (kg/m²)	Ca/Co¹	OR (95% CI)²	Ca/Co¹	OR (95% CI)²	Ca/Co¹	OR (95% CI)²
< 18.5	7/16	1.19 (0.43, 3.30)	18/16	1.70 (0.81, 3.56)	34/19	1.88 (1.04, 3.42)
18.5–20.0	19/35	1.77 (0.85, 3.67)	26/41	1.05 (0.59, 1.86)	100/77	1.34 (0.94, 1.92)
20.1–22.5	30/127	0.72 (0.40, 1.31)	107/126	1.41 (0.97, 2.07)	340/243	1.49 (1.16, 1.91)
22.6–25.0	32/127	1.00 (reference)	94/165	1.00 (reference)	242/265	1.00 (reference)
25.1–27.5	15/73	1.01 (0.50, 2.05)	63/100	1.15 (0.76, 1.74)	137/167	0.95 (0.71, 1.27)
>27.5	14/50	1.24 (0.59, 2.60)	44/62	1.45 (0.90, 2.33)	108/83	1.70 (1.20, 2.42)

^1.

N of cases / N of controls

^2.

Conditional logistic regression stratified by cohort, and adjusted for age, sex, and smoking.

^3.

p value for interaction between BMI and H.pylori is 0.3361

^4.

p value for interaction between BMI and H. pylori Omp/HP0305 status is 0.2628