Table 3.

Clinical features of pregnant patients with coronavirus disease 2019–associated hospital admissions

Characteristics	Case number
	12	37	27	25	19	16	31
Medical history
Age group, ya	30–35	30–35	30–35	20–25	20–25	30–35	30–35
Existing comorbidities	None	Previous smoker	Asthma, hypertension, hypothyroidism, Crohn’s disease on immunosuppressive medication	Asthma	Asthma, hypertension	Type 2 diabetes mellitus, hypertension	None
Pregnancy complications	Overweight	Asymmetrical IUGR (concern before COVID-19)	Class III obesity	Overweight	Class II obesity	Class III obesity	None
Prepregnancy BMI	26.3	26.2b	48.9	26.2	35.7	42.4	23.1
SARS-CoV-2 testing
Gestational age at symptom onset, wk	22.3	35.1	31.4	28.9	25	23	33.9
Gestational age at the first positive test, wk	22.7	35.9	31.9	29.4	25.3	23.7	34.1
Hospitalization
Timing
gestational age at hospitalization	23.6c	36.3	33.0	30.0	26.0	23.7	35.0
Number of days hospitalized	1	2	4	6, ICU for 3 days	8	4	3
Vital signs
Highest respiratory rate, breaths/min	20	22	32	49	28	28	32
Lowest oxygen saturation, %	96	94	96	82	92	95	92
Highest temperature, °C	37.0	38.0	37.2	37.3	38.4	38.8	37.7
Severity
Severe case?	Yes, dyspnea	Yes, dyspnea and infiltrates on CXR	Yes, RR≥30	Yes, RR≥30, oxygen saturation≤93%	Yes, oxygen saturation≤93%	No	Yes, RR≥30, oxygen saturation≤93%
Pulmonary imaging	Chest CT at GA 26.1 (normal)	CXR at GA 36.3 weeks with pulmonary infiltrates	CXR at GA 33.0 weeks with bilateral consolidations	CXR at GAs 29.4 and 30.0 weeks with bilateral consolidations, linear opacities	CXR at GAs 25.3 (normal), 26.1, and 26.4 weeks with bilateral consolidations	CXR at GA 23.7 weeks with unilateral consolidation	CXR at GA 35.0 weeks with patchy opacities
COVID-19 treatment	None	None	Remdesivir	Remdesivir, hydroxychloroquine	Azithromycin and oral prednisone (asthma)	Remdesivir, azithromycin, and ceftriaxone (pneumonia)	Pulmonary vasodilator
Respiratory support	Nasal cannula	Nasal cannula	None	High-flow nasal cannula	Nasal cannula	Nasal cannula	None
Delivery status at discharge?	Pregnant	Pregnant	Delivered by CD at GA 33.0 weeks; worsening respiratory status	Pregnant	Pregnant	Pregnant	Pregnant
Laboratory results during admission
Lowest hematocrit, %	34.0	34.0	30.0	30.7	31.5	31.8	32.0
Lowest platelets, 103 μL	196	128	118	171	241	112	197
Lowest WBC count, 103 μL	8.2	5.7	4.6	4.5	6.1	2.8	5.2
Highest WBC count, 103 μL	9.6	6.4	8.1	10	10.2	3.4	5.2
Lowest neutrophils, 103 μL	5.5	4.3	2.8	2.7	3.6	1.1	3.8
Lowest lymphocytes, 103 μL	3.3	1.1	0.9	0.6	1.5	0.8	18.4
Highest AST, units/L	12	12	46	29	22	45
Highest ALT, units/L	7	8	40	32	27	46
Highest D-dimer, μg/mL			0.2	4.08	0.25	0.31
Highest CRP, mg/L			1.6	9.3	5.8	5.2	9.9
Highest creatinine, mg/dL	0.51	0.47	0.66	0.6	0.77	0.51

ALT, alanine aminotransferase; AST, aspartate transaminase; BMI, body mass index; CD, cesarean delivery; COVID-19, coronavirus disease 2019; CRP, C-reactive protein; CT, computed tomography; CXR, chest X-ray; GA, gestational age; ICU, intensive care unit; IUGR, intrauterine growth restriction; RR, respiratory rate; SARS-CoV-2, severe acute respiratory syndrome coronavirus 2; WBC, white blood cells.

Lokken et al. COVID-19 in pregnant women in Washington State. Am J Obstet Gynecol 2020.

^aAge group (5-year increments) is presented to make it less likely that a patient might be identifiable.

^bPrepregnancy BMI not available. This value represents BMI at SARS-CoV-2 diagnosis, which was at 14 weeks’ gestation.

^cThis patient had 3 emergency department visits for respiratory concerns, 1 of which prompted this hospitalization.