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. 2020 May 14;13:4169–4181. doi: 10.2147/OTT.S245091

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© 2020 Guo et al.

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Metformin induces apoptosis in colon cancer cells in vitro. A flow cytometry-based method was conducted to test the effects of MET on the cellular apoptosis of the SW480 and SW620 cells in vitro. (A) Scatter plot (left) and histogram (right) of metformin induces apoptosis in SW480 cell. (B) Scatter plot (left) and histogram (right) of metformin induces apoptosis in SW620 cell. Early apoptotic cells are in the bottom-right field (Annexin V+/PI−). Late apoptotic cells are in the top-right field (Annexin V+/PI+). Data are represented as the mean ± SD. ***p-value<0.001.