Table 3.

Canonical pathways with significant enrichment in the ADHD–obesity gene-based meta-analysis.

	GABA Receptor Signaling	Corticotropin Releasing Hormone Signaling	Dopamine-DARPP32 Feedback in cAMP Signaling	Huntington’s Disease Signaling
P value	6.69 × 10−4	1.45 × 10−3	2.05 × 10−3	4.19 × 10−3
P value—B-H corrected	2.81 × 10−2	2.87 × 10−2	2.87 × 10−2	4.40 × 10−2
Canonical pathway size (number of genes)	128	143	165	270
ADHD–obesity genesa in the pathway	2	2	2	2
	CACNA1Db,c DNM1	BDNF CACNA1Db,c	CACNA1Db,c CSNK1G2	BDNF DNM1

^aGenes from the ADHD–obesity gene-based meta-analysis results, only considering genome-wide significant genes (at P_threshold = 2.97 × 10⁻⁶) with association P values lower by at least one order of magnitude in the meta-analysis compared to the gene-based results of both ADHD and obesity individually

^bAlso part of DOPA in the gene-set analysis

^cAlso part of CIRCA in the gene-set analysis