Fig. 3. Functional and microcircuit divergences based on biophysical modeling and functional connectivity analysis (left).

Schema of the connectome-informed biophysical simulation, showing a similar distribution of model parameters in our 65 HCs compared to a previous study²², and thalamo-cortical functional connectivity analysis (right). a Results from connectome-informed biophysical models, showing decreased subcortical drive but increased recurrent excitation–inhibition on cortico-cortical dynamics in 107 patients with TLE relative to 96 patients with GE. Black outlines indicate the boundaries of well-established intrinsic functional networks⁸⁶. b Differences in thalamo-cortical functional connectivity between TLE and GE. Findings were corrected for multiple comparisons at a family-wise error level of 0.05. For comparisons of TLE and GE relative to HCs, see Supplementary Fig. 1c.