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. 2020 May 18;11:2478. doi: 10.1038/s41467-020-16288-4

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 4 — a, b Top view and side view of one hSOAT1 dimer are shown in surface representation with semi-transparency. M1, M6 and M9 helices are shown as ribbons. c Close-up view of the dimer interface boxed by solid lines in b. Interacting residues were shown in sticks. Residues mutated in f were shown in orange. d A 180° rotated view compared to c. e Close-up view of the interacting residues boxed by dashed lines in b. f FSEC traces of hSOAT1 dimer with interface mutations. g The activities of hSOAT1 dimer mutants measured using NBD-cholesterol as substrate, in the presence of cholesterol. Source data are provided as a Source Data file (Data are shown as means ± standard deviations, n = 3 biologically independent samples).