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. 2020 May 18;10:8136. doi: 10.1038/s41598-020-65115-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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LncRNA expression profiles in the natural and premature aging models. (a) PCA plot summarizing the lncRNA expression profiles of the hearts of the different models of senescence. The plot has been generated using the first two principal components, which together account for the 34% of the variance between samples, n = 4 hearts for each mouse model. (b) VENN diagram showing the number of significantly differentially expressed lncRNAs in each aging model resulting from the comparison to the wild-type youngest timepoint. NA12W, natural aging 12 week-old; NA52W, natural aging 52 week-old; NA104W, natural aging 104 week-old.