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. 2020 May 18;10:8136. doi: 10.1038/s41598-020-65115-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Representation of the differences in the expression profiles between selected group comparisons. Volcano plots reporting the differentially expressed (a) mRNAs and (c) lncRNAs in the hearts of naturally aged and Harlequin mice compared to wild-type 12 week-old animals. In blue and yellow are the down- and up-regulated genes respectively. (b-d) Real-time PCR analysis of selected targets validates the RNA-sequencing results. *P < 0.05 vs wild-type 12 week-old mice; n refers to number of hearts.