Table 3.

Significant associations of smoking variables with white matter metrics.

	Cigarettes per day			Duration			Ever smoked
Region	β	p	q	β	p	q	β	p	q
Total white matter volume	−0.019	0.051	0.076	−0.009	0.028	0.042	0.009	0.713	0.713
White matter hyperintensity	0.011	0.235	0.235	0.001	0.727	0.727	0.124	5.89E−08	1.77E−07
Fractional anisotropy
Cingulate gyrus part of cingulum (L)	−0.001	0.916	0.985	0.002	0.570	0.905	−0.055	0.004	0.025
Posterior thalamic radiation (L)	0.003	0.722	0.985	0.006	0.148	0.443	−0.059	0.004	0.025
Superior thalamic radiation (L)	−0.006	0.450	0.985	0.002	0.508	0.832	−0.052	0.006	0.033
Superior thalamic radiation (R)	0.000	0.985	0.985	−0.001	0.823	0.963	−0.055	0.004	0.025
Mean diffusivity
Middle cerebellar peduncle	0.006	0.464	0.985	−0.004	0.270	0.539	0.070	0.0004	0.007
Medial lemniscus (R)	−0.004	0.641	0.985	0.001	0.685	0.963	0.060	0.002	0.022
Posterior thalamic radiation (L)	−0.007	0.405	0.985	−0.007	0.074	0.413	0.072	0.001	0.010
Posterior thalamic radiation (R)	−0.015	0.080	0.985	−0.001	0.769	0.963	0.091	0.00002	0.001
Superior thalamic radiation (L)	0.006	0.473	0.985	0.001	0.785	0.963	0.071	0.002	0.018
Superior thalamic radiation (R)	−0.001	0.931	0.985	0.003	0.502	0.832	0.094	0.0001	0.002

Standardized beta coefficients (β) and p values are reported for hurdle negative-binomial regression models of smoking variables predicting white matter metrics. Bold indicates FDR significance (q < 0.05). Full results are reported in Table S3.