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. 2020 May 18;5:41. doi: 10.1038/s41541-020-0190-9

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 6 — The liquid adjuvanted vaccine formulation MYM-V202 containing both P1 and rgp41 antigens served as reference material for comparison to the solid vaccine dosage form for nasal, oral, and sublingual delivery. A 3 months stability study was performed on the various liquid and solid vaccine forms stored under three different temperatures and relative humidity (RH) conditions: 4 °C (black line), 25 °C/65% RH (gray dot line, not done for the liquid form), and 40 °C/75% RH (gray line). P1 and rgp41 antigens were previously shown to be temperature sensitive, which is confirmed again here in the first two upper panels, showing rapid P1 and rgp41 modifications at 40 °C, as compared to the liquid vaccine stored under the recommended temperature at 4 °C. For solid vaccine forms, at each indicated month time point (M0, M1, M2, or M3), samples were reconstituted with water and analyzed by HPLC for the P1 and rgp41 content. Note that chemical modifications such as oxidation or deamidation on antigens are the main reasons to the observed lower antigen concentration, as antigen degradation could not be reported by native immunoblot. Data shown are from representative HPLC measures.