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. 2020 May 18;11(5):379. doi: 10.1038/s41419-020-2582-1

Fig. 2. Depletion of NETs by DNase I mitigate liver injury in MCDHF-fed mice.

Fig. 2

a Serum MPO-DNA levels were assessed in mice treated with PBS or DNase I with or without MCDHF diet (n = 6 per group). b Hepatic mRNA expression of inflammatory cytokines: Tnf, Il6, and Il1b, c mRNA expression of liver fibrosis hallmarks: Col1a1, Col3a1, and Acta2 and d ALT and GGT levels in the serum were determined in mice treated with MCDHF diet or control diet in the presence or absence of DNase I administration. e, f Representative images of H&E-stained or g, h Sirius Red-stained liver sections from mice treated with MCDHF diet for 2 weeks with or without DNase I administration. Inset: H&E or Sirius Red staining for control-diet group in the presence or absence of DNase I administration. Scale bars, 100 µm. Inflammatory and fibrosis areas were quantified. Data are presented as the mean ± SEM. Two-way ANOVA was used. *P < 0.05 vs. Ctrl. #P < 0.05 vs. MCDHF-treated alone.