Table 4.

Univariate and multivariate survival analysis of clinicopathological characteristics in CRC patients.

Feature	Disease-free survival				Overall survival
	Univariate		Multivariate		Univariate		Multivariate
	HR (95%CI)	p	HR (95%CI)	p	HR(95%CI)	p	HR(95%CI)	p
Gender (Female)	0.876(0.617–1.242)	0.457			0.866(0.605–1.241)	0.434
Age (≥60)	1.270(0.913–1.768)	0.155			1.416(0.935–1.988)	0.094
ALB (≧40 g/L)	0.944(0.624–1.428)	0.785			0.882(0.575–1.352)	0.564
BMI		0.600				0.738
Low	1.000				1.000
Normal	1.064(0.654–1.730)				1.023(0.627–1.667)
High	0.869(0.502–1.505)				0.873(0.503–1.517)
PNI (≥45)	1.001(0.716–1.399)	0.995			0.997(0.708–1.405)	0.987
NRS2002 (Non-nutrition risk group)	1.120(0.762–1.647)	0.565			1.140(0.770–1.687)	0.513
L3SMI (Low L3SMI)	1.649(1.164–2.335)	0.005	1.894(1.330–2.698)	<0.001	1.768(1.244–2.514)	0.001	2.030(1.420–2.902)	<0.001
pT stage (T3-4)	2.312(1.501–3.561)	<0.001	1.638(1.043–2.572)	0.032	2.351(1.501–3.681)	<0.001	1.657(1.036–2.648)	0.035
pN stage		<0.001		<0.001		<0.001		<0.001
N0	1.000		1.000		1.000		1.000
N1	2.096(1.415–3.105)		1.739(1.153–2.623)		2.049(1.370–3.066)		1.707(1.120–2.602)
N2	6.034(4.012–9.074)		4.530(2.855–7.187)		5.923(3.904–8.985)		4.486(2.800–7.188)
Tumor location (Colon)	0.877(0.630–1.222)	0.438			0.813(0.579–1.142)	0.233
Perineural/vascular invasion (Positive)	2.125(1.460–3.093)	<0.001	1.319(0.887–1.960)	0.171	2.002(1.362–2.942)	<0.001	1.247(0.831–1.871)	0.286
Pathological type		0.477				0.539
Protrude type	1.000				1.000
Infiltrating type	1.300(0.687–2.462)				1.349(0.708–2.568)
Ulcerative type	1.322(0.841–2.077)				1.281(0.807–2.035)
Differentiation(Medium/High)	0.453(0.292–0.703)	<0.001	0.744(0.462–1.198)	0.224	0.443(0.285–0.689)	<0.001	0.729(0.450–1.181)	0.200
CEA(≥5 ng/ml)	1.666(1.195–2.324)	0.003	1.425(1.005–2.020)	0.047	1.563(1.111–2.198)	0.010	1.387(0.970–1.983)	0.073
Postoperative chemoradiotherapy(Yes)	0.920(0.661–1.279)	0.618			0.879(0.628–1.230)	0.451