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. 2020 May 18;10:8134. doi: 10.1038/s41598-020-64756-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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VentA overcomes aminoglycoside resistance in MDR clinical isolates. Checkerboard broth microdilution assays showing dose-dependent potentiation of aminoglycoside antibiotic by VentA. (A,B,C) Represent the ability of venturicidin A to potentiate gentamicin, kanamycin and amikacin respectively against MRSA C1014. (D,E,F) Represent the broad-spectrum activity of the combination against MDR isolates, MRSA C1024, EF C0558 and PA C0089, respectively. Dark regions represent higher cell density. For staphylococci and enterococci; the 100% growth corresponds to an OD₆₀₀ of ~0.9 whereas for Pseudomonas it is ~0.4.