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. 2020 May 18;10:8134. doi: 10.1038/s41598-020-64756-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Effect of VentA on the action of bifunctional aminoglycoside-modifying enzyme, AAC(6′)-Ie-APH(2′′)-Ia. (A) AAC activity of bifunctional AME and (B) APH activity of bifunctional AME. VentA does not inhibit either of the enzymatic functions at the highest concentration tested, 112 μg/mL. The data are presented as mean ± standard deviation.