Table 1.
Antibacterial efficacy of gentamicin and VentA.
| Bacteria | Minimum Inhibitory Concentration (µg/mL) | Venturicidin A | ||
| Gentamicin | ||||
| − Venturicidin A | + Venturicidin A (8 µg/mL) | + Venturicidin A (16 µg/mL) | ||
| MRSA C1014 | 64 | 4 (0.125) | 4 (0.187) | >128 |
| MRSA C1139 | 32 | 4 (0.187) | 2 (0.187) | >128 |
| MRSA C1024 | 64 | 4 (0.125) | 4 (0.156) | >128 |
| MRSA C0115 | 16 | 2 (0.187) | 2 (0.250) | >128 |
| CMRSA-3 | 2 | 1 (1.062) | 1 (1.125) | >128 |
| M. smegmatis | 0.25 | 0.125 (0.58) | 0.125 (0.64) | >128 |
| E. faecium C0558 | 32 | 8 (0.312) | 4 (0.250) | >128 |
| E. faecium C0516 | 16 | 4 (0.312) | 4 (0.375) | >128 |
| P. aeruginosa C0060 | 32 | 4 (0.187) | 4 (0.250) | >128 |
| P. aeruginosa C0007 | 8 | 8 (1.062) | 4 (0.625) | >128 |
| P. aeruginosa C0089 | 16 | 4 (0.312) | 4 (0.375) | >128 |
| A. baumannii C0412 | 8 | 2 (0.312) | 2 (0.375) | >128 |
| A. baumannii C0074 | >64 | >64 | >64 | >128 |
| A. baumannii C0286 | >64 | >64 | >64 | >128 |
| E. coli BW25113 | 2 | 1 (1.062) | 1 (1.125) | >128 |
| E. coli C0001 | >64 | >64 | >64 | >128 |
| K. pneumoniae C0108 | >64 | 64 (0.56) | 64 (0.62) | >128 |
The values illustrated in parenthesis indicate the fractional inhibitory concentration index (FICI), measure of synergy (threshold ≤0.5). Though VentA does not have an MIC90, 128 µg/mL used as its lower limit MIC for FICI calculation.