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. 2020 May 18;11:2461. doi: 10.1038/s41467-020-16300-x

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Fig. 9 — TFEB overexpression in hepatocytes does not affect hepatocyte proliferation and identity in homeostasis conditions, while it induces differentiation of hepatocytes into ductular reaction (DR)-associated cholangiocytes after injury. Conversely, TFEB overexpression in cholangiocytes induces their proliferation and DR in homeostasis and upon liver injury. On the other hand, TFEB depletion in the liver impairs normal cell regeneration after injury due to reduced induction of Sox9 expression and decreased cell proliferation.