Table 2.

Bivariate correlations of clinical and MRI parameters with cavitation index

Variable	Spearman correlation coefficient	p value
Baseline variables
Age	− 0.096	0.47
NIHSS	0.060	0.65
Time stroke symptom onset to MRI at baseline	− 0.074	0.58
Time stroke symptom onset to MRI at follow-up 1 (BBB measurements)	− 0.083	0.53
Time stroke symptom onset to MRI at follow-up 2 (rating of tissue outcome)	− 0.203	0.12
RSSI maximal diameter	− 0.142	0.28
RSSI volume	− 0.140	0.29
WMH periventricular	− 0.092	0.49
WMH deep	− 0.178	0.18
WMH sum score	− 0.137	0.30
Deep atrophy score	− 0.210	0.11
Superficial atrophy score	− 0.138	0.31
Number of microbleeds	− 0.186	0.16
Number of old lacunes	0.118	0.37
DTI parameters at baseline
Median FA of normal-appearing white matter	− 0.001	1
Median MD of normal-appearing white matter	0.012	0.93
Median FA of RSSI (corrected for contralateral control region)	− 0.084	0.52
Median MD of RSSI (corrected for contralateral control region)	− 0.371	0.004
BBB measures at 1–3-month post-stroke*
Normalized AUC CSF	0.347	0.007
Normalized AUC gray matter	0.218	0.10
Normalized AUC white matter	0.080	0.55
Normalized AUC white matter lesions	0.109	0.41
Normalized AUC RSSI	− 0.014	0.92
Clinical outcome at 1 year
Modified Rankin scale	0.149	0.26
ACE-R [37] #	− 0.067	0.67

*BBB analyses were available in 59 patients (DCE data not available for 1 patient)

# Available in 42 patients

NIHSS, National Institutes of Health Stroke Scale; AUC, area under the curve; RSSI, recent small subcortical infarct; DTI, diffusion tensor imaging; WMH, white matter hyperintensities; MD, mean diffusivity; FA, fractional anisotropy; ACE-R, Addenbrooke’s Cognitive Examination Revised