Table 1.
Overview of patient cohort
| Patient collective | |
|---|---|
| Overview | 182 (160 male/22 female) |
| Average age | 63 [95% confidence interval: 62–65] |
| PCF†/no PCF† | 45 (25%)/137 (75%) |
| TNM | TNM-Status | Total (n‡) | PCF (%) | No PCF (%) |
|---|---|---|---|---|
| T-status | T1 | 8 | 1 (12.4) | 7 (87.5) |
| T2 | 45 | 17 (37.8) | 28 (62.2) | |
| T3 | 52 | 11 (21.2) | 41 (78.8) | |
| T4 | 69 | 15 (21.7) | 54 (78.3) | |
| Total | 174 | 44 (25.3) | 130 (74.7) | |
| N-status | N0 | 84 | 26 (31) | 58 (69) |
| N1 | 25 | 5 (20) | 20 (80) | |
| N2 | 63 | 13 (20.6) | 50 (79.4) | |
| N3 | 2 | 0 (0) | 2 (100) | |
| Total | 174 | 44 (25.3) | 130 (74.7) | |
| M-status | M0 | 169 (97%) | 43 (25.4) | 126 (74.6) |
| M1 | 5 (3%) | 1 (20) | 4 (80) | |
| Total | 174 (100%) | 44 (25.3) | 130 (74.7) | |
| Grading | G0 | 1 | 1 (100) | 0 (0) |
| G1 | 7 | 4 (57.1) | 3 (42.9) | |
| G2 | 97 | 21 (21.6) | 76 78.4) | |
| G3 | 63 | 16 (25.4) | 47 (74.6) | |
| Total | 168 | 42 (25) | 126 (75) |
| Main tumor | Tumour entity | Total (n‡) | PCF (%) | No PCF (%) |
|---|---|---|---|---|
| Hypopharynx | SCC* | 55 | 19 (34.5) | 36 (65.5) |
| Larynx | SCC* | 111 | 23 (20.7) | 88 (79.3) |
| Hypopharynx and Larynx | SCC* | 4 | 1 (25) | 3 (75) |
| Thyroid gland | Papillary | 2 | 0 (0) | 2 (100) |
| Follicular | 2 | 1 (50) | 1 (50) | |
| Total | 4 | 1 (25) | 3 (75) | |
| Synovial sarcoma | 2 | 0 (0) | 2 (100) | |
| non tumorous entities | Alkali burns | 2 | 1 (50) | 1 (50) |
| Laryngeal stenosis | 1 | 0 (0) | 1 (100) | |
| Radiogenic necrosis | 1 | 0 (0) | 1 (100) | |
| No specification | 2 | 0 (0) | 2 (100) |
| Risk factors | n Analysed | n‡ Applicable | PCF (%) | Non PCF (%) |
|---|---|---|---|---|
| Alcohol | 166 | 119 | 31 (26) | 88 (74) |
| Nicotine | 166 | 119 | 33 (27.7) | 86 (72.3) |
| Diabetes | 167 | 31 | 8 (25.8) | 23(74.2) |
| Previous RT§ | 182 | 20 | 4 (20) | 16 (80) |
| Previous RCT§ | 182 | 16 | 10 (62.5) | 6 (37.5) |
| Pectoralis Flap | 182 | 3 | 1 (33.3) | 2 (66.7) |
| Radialis Flap | 182 | 18 | 5 (27.8) | 13 (72.2) |
§RT radiotherapy; RCT radiochemotherapy
†PCF pharyngocutaneous fistula
‡ Number of valid cases; Percentage indication refers to number of valid cases
*squamous cell carcinoma