Fig. 6. Naftopidil/ABT-737 and Naftopidil/Trametinib combinations trigger cell death in PDOs.

Three PDOs were treated with Naftopidil (50 µM) and ABT-737 (5 µM) or Trametinib (100 nM) for 48 h. a Viability of PDOs was measured in each condition (histograms represent the percentage of viability in treated conditions normalized to that in control condition). b The effect of these combinations on PDOs morphology was assessed by optical microscopy (scale bar = 100 μm).