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. 2020 May 18;10:8178. doi: 10.1038/s41598-020-65180-0

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© The Author(s) 2020

Open Access This article is licensed under a Creative Commons Attribution 4.0 International License, which permits use, sharing, adaptation, distribution and reproduction in any medium or format, as long as you give appropriate credit to the original author(s) and the source, provide a link to the Creative Commons license, and indicate if changes were made. The images or other third party material in this article are included in the article’s Creative Commons license, unless indicated otherwise in a credit line to the material. If material is not included in the article’s Creative Commons license and your intended use is not permitted by statutory regulation or exceeds the permitted use, you will need to obtain permission directly from the copyright holder. To view a copy of this license, visit http://creativecommons.org/licenses/by/4.0/.

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Regulation of neuroinflammation by maternal LB supplementation in the two-week old offspring is mediated by transcriptional regulators. Transcripts of the IL-1β receptor Il1r1 (a) and the transcriptional regulators Cebpd (b) and Nfkbia (c) were evaluated by RT-PCR. Il1r1 gene expression was not affected by maternal LB supplementation (n = 5–6, (a). Cebpd (b) and Nfkbia (c) were upregulated by i.p. injection of IL-1β after four hours (n = 5-6). Maternal exposure of LB blocked the Il-1β-induced increased expression of these markers (n = 6–7). Data were normalized to Gapdh gene expression and are presented as mean ± SEM. Bars with ⎴ denote significant difference between experimental groups (at least p < 0.05).