Table 2.
Literature review of the number of reported extra-salivary malignant neoplasms seen in patients with Warthin tumor [8, 9, 11–51]
| References | Percent (%) of associated extra-salivary malignant neoplasms | Number of associated extra-salivary malignant neoplasms | Cases of Warthin tumor | Head and neck SCC | Lung | Other | Unknown origin |
|---|---|---|---|---|---|---|---|
| Zaccarini et al. current study | 37.0 | 27 | 73 | SCC (nostril) (1), SCC (tongue) (2), SCC (ear) (1) | SCC (4), adenocarcinoma (3) | Basal cell carcinoma (3), renal cell carcinoma (2), Breast carcinoma (2), melanoma (2), Non-Hodgkin lymphoma (1), peripheral T-cell lymphoma/leukemia (1) prostate adenocarcinoma (1), oligoastrocytoma (1), thyroid carcinoma (1), cholangiocarcinoma (1) | SCC (1) |
| Naumaan et al. [10] | 27.0 | 17 | 63 | SCC (5) | Adenocarcinoma (4), small cell carcinoma (2) | Non-Hodgkin lymphoma (2), Hodgkin lymphoma (1), myxoinflammatory sarcoma (1), breast carcinoma (1), renal carcinoma (1) | |
| Cardoso et al. [51] | 25.0 | 19 | 76 | SCC (larynx) (4), SCC (oral cavity or oropharynx) (4) | Basal cell carcinoma (5), thyroid carcinoma (2), prostate adenocarcinoma (1) breast carcinoma (1), uterine cervical carcinoma (1) | ||
| Maiorano et al. [8] | 11.5 | 9 | 78 | SCC of larynx (2) | SCC (2) | Non-Hodgkin lymphoma (1), urothelial cell carcinoma (bladder) (1), clear cell renal cell carcinoma (1), invasive ductal carcinoma (breast) (1), basal cell carcinoma (1) | |
| Seifert et al. [9] | 2.9 | 8 | 275 | SCC (auricle) (1), SCC (lip) (1), SCC (larynx) (1) | SCC (1) | Non-Hodgkin lymphoma (1), basal cell carcinoma (2) | SCC (parotid) (1) |
| Xu et al. [11] | 1.1 | 11 | 994 | SCC (tongue) (5), SCC (buccal) (2), SCC (floor of mouth) (2), SCC (oropharynx) (1) | Non-Hodgkin lymphoma (1) | ||
| Other studies/case reports | SCC (floor of mouth) (1), SCC (larynx) (4), SCC (hypopbarynx) (2), SCC (ear) (1), SCC (tongue) (1), SCC (oral cavity) (1), SCC (retromolar trigone) (1), SCC (frontal and ethmoid sinus) (1) | Non-small cell lung carcinoma (20), Small cell carcinoma (7) | Non-Hodgkin lymphoma (11), Hodgkin lymphoma (4), thyroid carcinoma (3), breast carcinoma (2), merkel cell carcinoma (2), T-cell lymphoblastic lymphoma (1), melanoma (1) | SCC (parotid) (13) |