Table 2.
Molecular profile of noninvasive follicular thyroid neoplasms with papillary-like nuclear features (NIFTP)
| References | Detection method | RAS | BRAFV600E | PPARG fusion | THADA fusion | BRAF other than V600E | EIF1AX | PTEN | No mutations found |
|---|---|---|---|---|---|---|---|---|---|
| Nikiforov et al. [19] | NGS | 8/27 (30%)a | 0/27 | 6/27 (22%) | 6/27 (22%) | 1/27 (4%) | 2/27 (7%)a | 0/27 | 6/27 (22%) |
| Zhao et al. [51] | NGS | 27/48 (56%) | 1/48 (2%) | 2/48 (4%) | NA | NA | NA | NA | 18/48 (38%) |
| Brandler et al. [52] | NGS | 18/27 (67%)b | 0/27 | 3/27 (11%) | 3/27 (11%) | 1/27 (4%)c | 1/27 (4%)c | 1/27 (4%) | 1/27 (4%) |
| Total | 53/102 (52%) | 1/102 (1%) | 11/102 (11%) | 9/54 (17%) | 2/54 (4%) | 3/54 (6%) | 1/54 (2%) | 25/102 (25%) |
NGS next generation sequencing
aTwo cases had concomitant RAS and EIF1AX mutations
bThree of the 18 were associated with concurrent mutations (TP53, n = 1; PTEN, n = 2)
cOne case showed two mutations EIF1AX and BRAF T599_R603