Table 2.
Protein identification of differentially expressed proteins in FNA samples of benign and MSGTs by MS/MS
| Spot no. | Id. | Protein name | Gene name | Theoretical Mw/pI | Matched peptides | Coverage (%) | Best ion score | FV MSGT vs. WT |
FV MSGT vs. PA |
|---|---|---|---|---|---|---|---|---|---|
| 1435 | P01857 | Ig gamma-1 chain C region | IGHG1 | 36,105/8.46 | 3 | 12 | 60.4 | ↓ 4.7 | ↓ 2.1 |
| 777 | P02675 | Fibrinogen beta chain | FGB | 55,928.6/8.54 | 15 | 32 | 73.5 | ns | ↓ 2.8 |
| 869 | P49189 | 4-trimethylaminobutyraldehyde dehydrogenase | ALDH9A1 | 53,802.0/5.69 | 7 | 17 | 83.2 | ↑ 1.7 | ↑ 2.1 |
| 1239 | P04083 | Annexin A1 | ANXA1 | 38,715.9/6.57 | 16 | 41 | 92.5 | ns | ↓ 2.5 |
| 1383 | P63244 | Guanine nucleotide-binding protein subunit beta-2-like 1 | GNB2L1 | 35,077.0/7.60 | 4 | 11 | 62.2 | ns | ↑ 3.0 |
| 1394 | Q9UL46 | Proteasome activator complex subunit 2 | PSME2 | 27,402.3/5.54 | 3 | 15 | 56.1 | ↑ 2.2 | ↑ 3.2 |
| 1401 | P47756 | F-actin-capping protein subunit beta | CAPZB | 31,351.6/5.36 | 9 | 39 | 101.0 | ↑ 3.0 | ↑ 3.0 |
| 1438 | Q06323 | Proteasome activator complex subunit 1 | PSME1 | 28,723.9/5.78 | 4 | 13 | 67.6 | ↑ 1.6 | ↑ 2.3 |
| 1904 | P02511 | Alpha-crystallin B chain | CRYAB | 20,159.5/6.76 | 4 | 14 | 42.9 | ns | ↓ 6.8 |
| 2162 | P23528 | Cofilin-1 OS = Homo sapiens | CFL1 | 18,503.2/8.22 | 5 | 39 | 78.0 | ↑ 5.3 | ↑ 4.0 |
| 2565 | P06702 | Protein S100-A9 | S100A9 | 13,242.37/5.71 | 3 | 32 | 43.8 | ns | ↑ 4.8 |
| 2953 | P52907 | F-actin-capping protein subunit alpha-1 | CAPZA1 | 32,923.2/5.45 | 5 | 26 | 87.1 | ns | ↑ 2.9 |
| 2046 | P00441 | Superoxide dismutase[Cu–Zn] | SOD1 | 15,935/5.7 | 12 | 41 | 94 | ↑ 2.8 | ns |
| 1058 | P40121 | Macrophage-capping protein | CAPG | 38,498/5.82 | 7 | 20 | 58 | ↑ 3.1 | ns |
| 2276 | P62937 | Peptidyl-prolyl-cis–trans isomerase A | PPIA | 18,012.49/7.68 | 5 | 41 | 67 | ↑ 3.6 | ↑ 1.6 |
| 2294 | P62937 | Peptidyl-prolyl-cis–trans isomerase A | PPIA | 18,012.49/7.68 | 6 | 38 | 45 | ↑ 4.0 | ↑ 2.0 |
| 1284 | P08758 | Annexin 5 | ANXA5 | 35,805.58/4.93 | 5 | 35 | 101 | ↑ 3.4 | ↑ 5.0 |
Abbreviations: MW molecular weight; pI isoelectric point; ns not significant; FV fold variation; MSGT malignant salivary gland tumor; PA pleomorphic adenoma; WT Warthin’s tumor; FNA fine needle aspiration