Table 1.
Summarization of the prominent applications of the phenomenon of hydrodynamic focusing for disease diagnostic applications
| Research groups | Cell/macromolecule targeted | Parameters analyzed | Diagnostic applications |
|---|---|---|---|
| Zhan et al. [92] | Erythrocytes | Release profiles as a function of time and distance traveled. | Diabetes mellitus, myocardial infarction, hypertension, sickle cell anemia |
| Moehlenbrock et al. [93] | Erythrocytes, ATP | ATP release data as a function of RBC deformability | Pulmonary hypertension scleroderma, chronic obstructive lung disease |
| Koh et al. [94] | Liposomes | Average particle size, zeta potential, and morphology of the lipopolyx particles. | Cancer treatment |
| Frankowski et al. [95] [96] | Leukocyte subsets: CD3+, CD4+, CD8+, CD19+, CD3− | Fluorescent intensity detection, scatter plot and pulse height distribution | Malaria, Kala Azar, Hypothyroidism, Tuberculosis, HIV |
| Kent et al. [97] | Thrombocytes | Adhesion results from surface coverage of VWF coating | Cardiovascular diseases, cancer metastasis, diabetes |
| Zheng et al. [102] | Erythrocytes | Deformation index via the folding mode, time constant or recovery rate | Reliable quantification of stored blood quality for effective treatment |