Table 2.
Levels of claudin-1, -4 and -7 expression in odontogenic tumors
| Claudins | Odontogenic tumors | Immunohistochemical staining, n (%) | Expression levels, n (%) | P-value | |||||
|---|---|---|---|---|---|---|---|---|---|
| Level 0 | Level 1+ | Level 2+ | Level 3+ | Level 4+ | Low | High | |||
| Claudin-1 |
AM AOTa AF ACa |
1 (2.3) 0 (0) 0 (0) 2 (66.7) |
10 (23.3) 0 (0) 3 (50.0) 1 (33.3) |
11 (25.6) 2 (11.8) 0 (0) 0 (0) |
13 (30.2) 10 (58.8) 0 (0) 0 (0) |
8 (18.6) 5 (29.4) 3 (50.0) 0 (0) |
11 (25.6) 0 (0) 3 (50.0) 3 (100) |
32 (74.4) 17 (100) 3 (50.0) 0 (0) |
0.005 |
| Claudin-4 |
AMb,c AOTb AFc AC |
17 (39.5) 14 (82.4) 6 (0) 2 (66.7) |
20 (46.5) 3 (17.6) 0 (0) 1 (33.3) |
4 (9.3) 0 (0) 0 (0) 0 (0) |
2 (4.7) 0 (0) 0 (0) 0 (0) |
0 (0) 0 (0) 0 (0) 0 (0) |
37 (86.0) 17 (100) 6 (100) 3 (100) |
6 (14.0) 0 (0) 0 (0) 0 (0) |
0.002 |
| Claudin-7 |
AMd AOTd AF AC |
2 (4.7) 1 (5.9) 1 (16.7) 0 (0) |
6 (14.0) 1 (5.9) 1 (16.7) 0 (0) |
8 (18.6) 1 (5.9) 1 (16.7) 1 (33.3) |
18 (41.7) 2 (11.8) 0 (0) 2 (66.7) |
9 (20.9) 12 (70.6) 3 (50.0) 0 (0) |
8 (18.6) 2 (11.8) 2 (33.3) 0 (0) |
35 (81.4) 15 (88.2) 4 (66.7) 3 (100) |
0.046 |
Analyses of comparison were performed using Kruskal–Wallis test
Tumor pairs labelled by letters a, b, c and d showed statistically significant differences in the expression of the designated claudins using post hoc pairwise comparison tests