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. 2020 May 12;10:589. doi: 10.3389/fonc.2020.00589

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Copyright © 2020 Liu, Zhou, Wang, Zhu, Deng, Li, Zhou, Chen, Li, Xie, Zeng, Wang and Fu.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The expression of high-mobility group AT-hook 1 (HMGA1) and its correlation with miR-221 in bladder cancer (BC). (A) Heatmap diagram of differential miRNAs which were positively correlated with HMGA1 in The Cancer Genome Atlas (TCGA) database (left). The correlation between HMGA1 and miR-221, miR-221 and TP53INP1, and HMGA1 and TP53INP1 were examined in 402 cases of BC samples in the TCGA database (right). (B) The effects of siHMGA1 on the expression of HMGA1, miR-221, and TP53INP1 in 5637 and T24 cells were determined by RT-qPCR. (C) Expression of HMGA1 in BC samples (red box) and adjacent tissues (gray box). (D) The Kaplan–Meier survival analysis of low and high level of HMGA1 from the TCGA database. (E) The expression of HMGA1 was determined by RT-qPCR in BC cell lines. SV-HUC-1 was used as a normal control. (F) Immunohistochemistry (IHC) staining of HMGA1 in 64 BC tissues and paired 48 adjacent non-tumor tissues obtained from patients with BC. Scale bar, 50 μm. *p < 0.05, **p < 0.01, ***p < 0.001, and ****p < 0.0001.