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. 2020 May 12;11:893. doi: 10.3389/fimmu.2020.00893

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Copyright © 2020 Kanoi, Nagaoka, White, Morita, Palacpac, Ntege, Balikagala, Yeka, Egwang, Horii, Tsuboi and Takashima.

This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY). The use, distribution or reproduction in other forums is permitted, provided the original author(s) and the copyright owner(s) are credited and that the original publication in this journal is cited, in accordance with accepted academic practice. No use, distribution or reproduction is permitted which does not comply with these terms.

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The number of antigenic targets recognized by different age-groups at study enrollment. The number of seropositive RIFINs, STEVORs, and SURFINs for each individual is shown. Box-plots indicate the median and interquartile range for each group. (A) As categorized by age: Statistical difference was assessed using the Kruskal–Wallis test (P <0.001); with Dunn's test as post hoc test, P <0.01 between age 6–10 and 16–20 years for all protein families. (B) As categorized by febrile malaria outcome during the follow-up period. There was no statistical difference between individuals who developed febrile malaria and those who did not develop malaria.